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Being "one of the guys" can mean a lot of great things: poker games, pick-up softball games, watching sports or just hanging out at a favorite bar. But for PJ Franklin, played by Jordana Spiro (JAG, Must Love Dogs), being a girl who’s one of the guys can be challenging.

PJ (Jordana Spiro) is a twenty-something sports reporter for the Chicago Sun Times. At first glance, she’s a typical young single woman--smart, attractive, outgoing, personable. Her boys are her family, which sometimes hinders PJ's dating life, as the men she tries to date don't know how to react to her unconventional interests and the all-important men in her life.

PJ’s group of friends includes her brother, Andy (Jim Gaffigan), whose wife keeps him on an all-too-short leash; Mike (Jamie Kaler), a commitment-challenged ladies man who works for the Chicago Cubs; Kenny (Michael Bunin), a sports-memorabilia store owner who hasn't mastered the art of dating; and Brendan (Reid Scott), a hard-rock DJ whose on-again, off-again romance with his girlfriend often leaves him crashing at PJ's apartment; and the most recent addition to the group, Bobby (Kyle Howard) a sportswriter for the Chicago Tribune, the Windy City's rival newspaper. PJ's friend Stephanie (Kellee Stewart), who she's known since journalism school, does her best to give PJ advice on men and dating from a more female point-of-view.